(2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

Base Information

Chemical Name:(2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide
CAS No.:160238-48-2
Molecular Formula:C₂₃H₄₁NO₅Si
Molecular Weight:439.668
Hs Code.:

Synonyms:(2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

Suppliers and Price of (2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

There total 5 articles about (2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160238-45-9
(2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol

: 160238-48-2
(2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) CH₂Cl₂, from -78 to 0 deg C, 1 h

2: 1.) n-Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, a) -78 deg C, 3 h, b) 0 deg C, 2 h

3: 1.) Me₃Al / 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, RT, 12 h

4: imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; dimethyl sulfoxide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00811-3

Reference yield:

: 160238-46-0
(2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal

: 160238-48-2
(2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, a) -78 deg C, 3 h, b) 0 deg C, 2 h

2: 1.) Me₃Al / 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, RT, 12 h

3: imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00811-3

Reference yield:

: (R)-3-[(R)-3-Hydroxy-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pentanoyl]-4-isopropyl-oxazolidin-2-one

: 160238-48-2
(2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Me₃Al / 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, RT, 12 h

2: imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; trimethylaluminum; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00811-3