2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone

Base Information

• Chemical Name: 2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone
• CAS No.: 1332862-57-3
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.622
• Mol file: 1332862-57-3.mol

Synonyms:2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone

Chemical Property of 2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone

Chemical Property:

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone

There total 1 articles about 2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-(Chloroacetyl)-2-hydroxybenzaldehyde (115787-51-4) → 2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone (1332862-57-3)

Guidance literature:

With sodium tetrahydroborate; In acetic acid; at 5 - 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1135/cccc2011029

Reference yield:

2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone (1332862-57-3) → (S)-salbutamol acetate (35459-11-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C

2.1: sodium tetrahydroborate / methanol / 0 - 20 °C

3.1: Burkholderia cepacia lipase; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 0.08 h / Inert atmosphere

3.2: 48 h / 40 °C / Inert atmosphere

4.1: lithium hydroxide / ethanol / 1 h / 20 °C

5.1: 120 h / 70 °C

6.1: water / 3 h / 50 °C

With Burkholderia cepacia lipase; sodium tetrahydroborate; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; water; sodium carbonate; toluene-4-sulfonic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

DOI:10.1135/cccc2011029

Reference yield:

2-chloro-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone (1332862-57-3) → (S)-2,2-dimethyl-6-(oxiran-2-yl)-4H-benzo[1,3]dioxin (1332862-61-9,54208-71-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C

2.1: sodium tetrahydroborate / methanol / 0 - 20 °C

3.1: Burkholderia cepacia lipase; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 0.08 h / Inert atmosphere

3.2: 48 h / 40 °C / Inert atmosphere

4.1: lithium hydroxide / ethanol / 1 h / 20 °C

With Burkholderia cepacia lipase; sodium tetrahydroborate; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate; toluene-4-sulfonic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

DOI:10.1135/cccc2011029

upstream raw materials:

5-(Chloroacetyl)-2-hydroxybenzaldehyde

Downstream raw materials:

(S)-2,2-dimethyl-6-(oxiran-2-yl)-4H-benzo[1,3]dioxin

(S)-salbutamol acetate