(S)-salbutamol acetate

Base Information

• Chemical Name: (S)-salbutamol acetate
• CAS No.: 35459-11-1
• Molecular Formula: C₂H₄O₂*C₁₃H₂₁NO₃
• Molecular Weight: 299.367
• Mol file: 35459-11-1.mol

Synonyms:

Chemical Property of (S)-salbutamol acetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-salbutamol acetate

There total 11 articles about (S)-salbutamol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic acid (64-19-7,77671-22-8) + (S)-2-(tert-butylamino)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)ethanol → (S)-salbutamol acetate (35459-11-1)

Guidance literature:

With water; at 50 ℃; for 3h;

DOI:10.1135/cccc2011029

Reference yield: 79.0%

α-[(benzyl-tert-butylamino)methyl]-m-xylene-4,α,α'-triol (24085-03-8) + acetic acid (64-19-7,77671-22-8) → acetate salt of salbutamol (35459-11-1,35459-13-3)

Guidance literature:

2-[benzyl(tert-butyl)amino]-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanol; With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 1h; under 760.051 Torr;

acetic acid; In methanol; at 20 ℃;

DOI:10.1021/acs.oprd.7b00261

Reference yield:

C13H17Cl4NO3Si + acetic acid (64-19-7,77671-22-8) → acetate salt of salbutamol (35459-11-1,35459-13-3)

Guidance literature:

C₁₃H₁₇Cl₄NO₃Si; With ammonia borane; In diethyl ether; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

acetic acid; In water; at 60 ℃; for 5h; Inert atmosphere;

DOI:10.1002/chem.201500210

upstream raw materials:

acetic acid

tert-butylisonitrile

4-hydroxy-3-(hydroxymethyl)benzaldehyde

α-[(benzyl-tert-butylamino)methyl]-m-xylene-4,α,α'-triol