2-(7-Hydroxy-1-naphthyl)ethylaMine

Base Information

• Chemical Name: 2-(7-Hydroxy-1-naphthyl)ethylaMine
• CAS No.: 148018-62-6
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.241
• Mol file: 148018-62-6.mol

Synonyms:(7-hydroxy-1-naphthyl)ethanamine

Chemical Property of 2-(7-Hydroxy-1-naphthyl)ethylaMine

Chemical Property:

• Boiling Point: 378.4±17.0 °C(Predicted)
• PKA: 9.28±0.40(Predicted)
• Density: 1.181±0.06 g/cm3(Predicted)

Purity/Quality:

≥99.0% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(7-Hydroxy-1-naphthyl)ethylaMine

There total 4 articles about 2-(7-Hydroxy-1-naphthyl)ethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(7-hydroxy-1-naphthyl)acetonitrile (1079774-32-5) → (7-hydroxy-1-naphthyl)ethanamine (148018-62-6)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; at 40 ℃; under 0.375038 Torr;

Reference yield:

7-hydroxy-1-tetralone (22009-38-7) → (7-hydroxy-1-naphthyl)ethanamine (148018-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-hydroxy-benzoic acid; benzylamine / toluene / 6 h / 108 - 110 °C

2: palladium on activated charcoal / toluene / 30 h / Reflux

3: ammonium hydroxide; hydrogen / methanol / 40 °C / 0.38 Torr

With ammonium hydroxide; palladium on activated charcoal; hydrogen; benzylamine; 4-hydroxy-benzoic acid; In methanol; toluene;

Reference yield:

2-(7-hydroxynaphthalen-1-yl)ethylamine hydrochloride → (7-hydroxy-1-naphthyl)ethanamine (148018-62-6)

Guidance literature:

With potassium carbonate; In water; for 2h; pH=9;

upstream raw materials:

7-hydroxy-1-tetralone

(7-hydroxy-1-naphthyl)acetonitrile

(7-hydroxy-3,4-dihydro-1-naphthalenyl)acetonitrile

Refernces

• 1、 Picard, I. le,Depreux, P.,Lesieur, I.,Delagrange, P.,Bennejean, C.,Renard, P.,Voisin, P.. "Design and Synthesis of Naphthalenic Derivatives as Potential Inhibitors of Hydroxyindole-O-methyltransferase". . p. 183 - 188. Retrieved 2007/10/03.