22009-38-7

Basic information

• Product Name: 7-Hydroxy-1-tetralone
• Synonyms: 7-Hydroxy-3,4-dihydronaphthalen-1(2H);1(2H)-Naphthalenone,3,4-dihydro-7-hydroxy-;7-HYDROXY-1-TETRALONE;7-Hydroxy-3,4-dihydro-2H-naphthalen-1-one;7-hydroxyl-1-tetralone;4-dihydro-7-hydroxy-;7-hydroxy-3,4-dihydronaphthalen-1(2H)-one;7-Hydroxy-1-tetralone 7-Hydroxy-3,4-dihydronaphthalen-1(2H)
• CAS NO: 22009-38-7
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.19
• EINECS: 219-048-0
• Mol File: 22009-38-7.mol
• Article Data: 27

Chemical Properties

• Melting Point: 164.0 to 168.0 °C
• Boiling Point: 215°C/12mmHg(lit.)
• Flash Point: 146.8 °C
• Appearance: /
• Density: 1.236 g/cm³
• Vapor Pressure: 3.25E-05mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.44±0.20(Predicted)
• CAS DataBase Reference: 7-Hydroxy-1-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxy-1-tetralone(22009-38-7)
• EPA Substance Registry System: 7-Hydroxy-1-tetralone(22009-38-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 22009-38-7(Hazardous Substances Data)

Usage

Uses

7-Hydroxy-1-tetralone, its derivatives and related fluorescent chalcones have been used as pharmacological tools to study the human histamine H3 receptor. Also C7-Substituted α-Tetralone derivatives have been study as Inhibitors of Monoamine Oxidase.

InChI:InChI=1/C10H10O2/c11-8-5-4-7-2-1-3-10(12)9(7)6-8/h4-6,11H,1-3H2

Upstream product

• 6836-19-7 7-Methoxy-1-tetralone 
• 67730-57-8 3-nitro-2-cyclohexen-1-ol 
• 77970-17-3 3-nitrocyclohex-2-ene-1-one 
• 58008-75-6 7-Oxa-bicyclo[4.1.0]heptan-2-one oxime 
• 1125-78-6 5,6,7,8-Tetrahydro-2-naphthol 
• 575-38-2 1,7-Dihydroxynaphthalene 
• 51417-24-4 4a-acetoxy-5,6,7,8-tetrahydro-4aH-naphthalen-2-one 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 22129-60-8 1,2,3,4-tetrahydronaphthalene-1,7-diol 
• 32263-64-2 7-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one 
• 1539310-37-6 7-phenethyloxy-3,4-dihydro-2H-naphthalen-1-one 
• 1462951-39-8 7-amino-1-methyl-8-(propan-2-yloxy)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 1462951-42-3 1-methyl-7-nitro-8-(propan-2-yloxy)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 1462951-41-2 7-nitro-8-(propan-2-yloxy)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 1462951-40-1 8-(propan-2-yloxy)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 776328-39-3 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 
• 1275584-73-0 1-(3'-methylbut-2'-enyl)-8-(triisopropylsilyloxy)-5,6-dihydronaphthalen-2-ol 
• 1275584-72-9 3-(3'-methylbut-2'-enyl)-8-(triisopropylsilyloxy)-5,6-dihydronaphthalen-2-ol 
• 1275584-71-8 (7-(2'-methylbut-3'-en-2'-yloxy)-3,4-dihydronaphthalen-1-yloxy)triisopropylsilane 
• 1275584-69-4 7-hydroxy-6-(3'-methylbut-2'-enyl)tetralone 
• 1275584-70-7 7-hydroxy-8-(3'-methylbut-2'-enyl)tetralone 
• 1275584-68-3 7-(2'-methylbut-3'-en-2'-yloxy)-1-tetralone 

Relevant articles and documents

Highly regioselective oxygenation of C-H bonds: Diamidomanganese constructs with attached substrates as catalyst models

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Synthesis and evaluation of tetrahydroisoquinoline derivatives against Trypanosoma brucei rhodesiense

Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by the parasitic protozoan Trypanosoma brucei (T. b.), and affects communities in sub-Saharan Africa. Previously, analogues of a tetrahydroisoquinoline scaffold were reported as having in vitro activity (IC50 = 0.25–70.5 μM) against T. b. rhodesiense. In this study the synthesis and antitrypanosomal activity of 80 compounds based around a core tetrahydroisoquinoline scaffold are reported. A detailed structure activity relationship was revealed, and five derivatives (two of which have been previously reported) with inhibition of T. b. rhodesiense growth in the sub-micromolar range were identified. Four of these (3c, 12b, 17b and 26a) were also found to have good selectivity over mammalian cells (SI > 50). Calculated logD values and preliminary ADME studies predict that these compounds are likely to have good absorption and metabolic stability, with the ability to passively permeate the blood brain barrier. This makes them excellent leads for a blood-brain barrier permeable antitrypanosomal scaffold.

POLYMERIZABLE ABSORBERS OF UV AND HIGH ENERGY VISIBLE LIGHT

Described are polymerizable high energy light absorbing compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and X are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Process for preparing 7-hydroxy-3,4-dihydro-2H-1-naphthalenone

The invention discloses a process for preparing 7-hydroxy-3,4-dihydro-2H-1-naphthalenone. The process comprises preparation processes of salting reactions and hydrolysis reactions. The method for preparing 7-hydroxy-3,4-dihydro-2H-1-naphthalenone, which is disclosed by the invention, has the advantages that the fineness of aluminum trichloride is lowly required, only one solvent is used, the solvent is simple to recycle and treat, the production cost is low, the yield is high, the product purity is high, the process is applicable to industrial production.