1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride

Base Information

Chemical Name:1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride
CAS No.:75209-93-7
Molecular Formula:C₂₄H₃₁NO*ClH
Molecular Weight:385.977
Hs Code.:

Synonyms:1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride

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Chemical Property of 1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride

There total 11 articles about 1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15547-89-4
2-(3-methoxyphenyl)cyclohexanone

: 75209-93-7
1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: 80.2 percent / TsOH / toluene / 20 h / Heating

2: benzene / 18 h / Heating

3: 2N HCl / benzene / 3 h / Ambient temperature

4: 61.2 percent / TsOH / benzene / 75 h / Heating

5: 1.) hydrazine hydrate, conc. HCl, 2.) KOH / 1.) triethylene glycol, 130 deg C, 7 h, 2.) triethylene glycol, 210 deg C, 4 h

6: 580 mg / conc. HCl / ethanol; diethyl ether / 1.5 h / Ambient temperature

7: 85 percent / NH₂OH*HCl, NaOAc*3H₂O / ethanol / 1 h / Heating

8: 4.6 g / LiAlH₄ / tetrahydrofuran / 3 h / Heating

9: 78.7 percent / K₂CO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

10: 1.) NaBH₄, BF₃*Et₂O, 2.) 23percent HCl / 1.) THF, room temp., overnight, 2.) EtOH, Et₂O, room temp., 3 h

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; diethyl ether; ethanol; water; toluene; benzene;
DOI:10.1248/cpb.28.1022

Reference yield:

: 75209-39-1
morpholine enamine of 2-(m-methoxyphenyl)cyclohexanone

: 75209-93-7
1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: benzene / 18 h / Heating

2: 2N HCl / benzene / 3 h / Ambient temperature

3: 61.2 percent / TsOH / benzene / 75 h / Heating

4: 1.) hydrazine hydrate, conc. HCl, 2.) KOH / 1.) triethylene glycol, 130 deg C, 7 h, 2.) triethylene glycol, 210 deg C, 4 h

5: 580 mg / conc. HCl / ethanol; diethyl ether / 1.5 h / Ambient temperature

6: 85 percent / NH₂OH*HCl, NaOAc*3H₂O / ethanol / 1 h / Heating

7: 4.6 g / LiAlH₄ / tetrahydrofuran / 3 h / Heating

8: 78.7 percent / K₂CO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

9: 1.) NaBH₄, BF₃*Et₂O, 2.) 23percent HCl / 1.) THF, room temp., overnight, 2.) EtOH, Et₂O, room temp., 3 h

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; diethyl ether; ethanol; water; benzene;
DOI:10.1248/cpb.28.1022

Reference yield:

: 75209-40-4
1-(m-methoxyphenyl)bicyclo<3.3.1>nonane-2,9-dione

: 75209-93-7
1-(m-methoxyphenyl)-9-phenethylaminobicyclo<3.3.1>nonane hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 61.2 percent / TsOH / benzene / 75 h / Heating

2: 1.) hydrazine hydrate, conc. HCl, 2.) KOH / 1.) triethylene glycol, 130 deg C, 7 h, 2.) triethylene glycol, 210 deg C, 4 h

3: 580 mg / conc. HCl / ethanol; diethyl ether / 1.5 h / Ambient temperature

4: 85 percent / NH₂OH*HCl, NaOAc*3H₂O / ethanol / 1 h / Heating

5: 4.6 g / LiAlH₄ / tetrahydrofuran / 3 h / Heating

6: 78.7 percent / K₂CO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

7: 1.) NaBH₄, BF₃*Et₂O, 2.) 23percent HCl / 1.) THF, room temp., overnight, 2.) EtOH, Et₂O, room temp., 3 h

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; diethyl ether; ethanol; water; benzene;
DOI:10.1248/cpb.28.1022