3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Base Information

Chemical Name:3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde
CAS No.:1307812-55-0
Molecular Formula:C₂₂H₁₃F₃N₂O₃
Molecular Weight:410.352
Hs Code.:

Synonyms:3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

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Chemical Property of 3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

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Technology Process of 3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

There total 7 articles about 3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1307812-53-8
3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

: 1307812-55-0
3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Guidance literature:: 3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; at 20 ℃;

With sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307812-55-0
3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

3.2: 20 °C

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.58 h / 20 °C

5.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 0.5 h / -78 °C / Inert atmosphere

5.3: 0.5 h / -78 °C

6.1: thionyl chloride; pyridine / toluene / 0.75 h / 20 - 90 °C

7.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

7.2: 0.5 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; osmium(VIII) oxide; chloro-trimethyl-silane; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; diazomethyl-trimethyl-silane; In tetrahydrofuran; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1307812-55-0
3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 1,2-dichloro-ethane / 20 °C

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

2.2: 20 °C

3.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.58 h / 20 °C

4.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 0.5 h / -78 °C / Inert atmosphere

4.3: 0.5 h / -78 °C

5.1: thionyl chloride; pyridine / toluene / 0.75 h / 20 - 90 °C

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

6.2: 0.5 h / 20 °C / Inert atmosphere

With pyridine; osmium(VIII) oxide; chloro-trimethyl-silane; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; diazomethyl-trimethyl-silane; In tetrahydrofuran; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;