(S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide

Base Information

Chemical Name:(S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide
CAS No.:1365533-60-3
Molecular Formula:C₂₁H₃₀INO₃SSi
Molecular Weight:531.53
Hs Code.:

Synonyms:(S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide

Chemical Property:

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Technology Process of (S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide

There total 4 articles about (S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₆INO₃S

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1365533-60-3
(S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.tetlet.2012.01.037

Reference yield:

: 1270293-83-8
(S)-(+)-2-(2-iodophenyl)glycine methyl ester

: 1365533-60-3
(S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 16 h / 0 - 20 °C

2.2: 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.01.037

Reference yield:

: 1380502-07-7
C₁₆H₁₆INO₄S

: 1365533-60-3
(S)-N-(2-((tert-butyldimethylsilyl)oxy)-1-(2-iodophenyl)ethyl)-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 16 h / 0 - 20 °C

1.2: 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.01.037