methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester

Base Information

Chemical Name:methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester
CAS No.:1400590-87-5
Molecular Formula:C₂₁H₁₉N₅O₅S
Molecular Weight:453.478
Hs Code.:

Synonyms:methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester

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Chemical Property of methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester

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Technology Process of methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester

There total 7 articles about methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1400590-86-4
1-(1-{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}-1H-[1,2,3]triazol-4-ylmethyl)-1H-pyrimidine-2,4-dione

: 124-63-0
methanesulfonyl chloride

: 1400590-87-5
methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;
DOI:10.1016/j.tet.2012.07.093

Reference yield:

: 1400590-84-2
2-{3-[2-(3-azidoprop-1-ynyl)phenyl]prop-2-ynyloxy}tetrahydropyran

: 1400590-87-5
methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate; sodium ascorbate / water; tert-butyl alcohol / 10 h / 20 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / ethanol / 8 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; pyridinium p-toluenesulfonate; sodium ascorbate; triethylamine; In ethanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.tet.2012.07.093

Reference yield:

: 1026064-38-9
methanesulfonic acid 3-{2-[3-(tetrahydropyran-2-yloxy)prop-1-ynyl]phenyl}prop-2-ynyl ester

: 1400590-87-5
methanesulfonic acid 3-(2-{3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,2,3]triazol-1-yl]prop-1-ynyl}phenyl)prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2: copper(ll) sulfate pentahydrate; sodium ascorbate / water; tert-butyl alcohol / 10 h / 20 °C / Inert atmosphere

3: pyridinium p-toluenesulfonate / ethanol / 8 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With sodium azide; copper(ll) sulfate pentahydrate; pyridinium p-toluenesulfonate; sodium ascorbate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tet.2012.07.093