N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

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Chemical Name:N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide
CAS No.:1228465-85-7
Molecular Formula:C₂₅H₂₂FN₅O₄S
Molecular Weight:507.545
Hs Code.:

Synonyms:N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

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Chemical Property of N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

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Technology Process of N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

There total 8 articles about N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1125632-05-4
N-[5-(3-amino-4-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

: 1758-46-9
2-phenoxyethanamine

: 1228465-85-7
N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: bis(trichloromethyl) carbonate; N-[5-(3-amino-4-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

2-phenoxyethanamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 62257-16-3
5-hydroxy-2-fluoroaniline

: 1228465-85-7
N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: tetrahydrofuran / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: bromine; acetic acid / 20 °C / Cooling with ice

5.1: dmap; pyridine / 20 °C / Cooling with ice

6.1: trifluoroacetic acid / 0.5 h / 20 °C

7.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

7.2: 3 h / 20 °C

With pyridine; dmap; hydrogen; bromine; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1228465-85-7
N-[5-(4-fluoro-3-{[(2-phenoxyethyl)carbamoyl]amino}phenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: tetrahydrofuran / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: bromine; acetic acid / 20 °C / Cooling with ice

5.1: dmap; pyridine / 20 °C / Cooling with ice

6.1: trifluoroacetic acid / 0.5 h / 20 °C

7.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

7.2: 3 h / 20 °C

With pyridine; dmap; hydrogen; bromine; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;