[(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine

Base Information

• Chemical Name: [(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine
• CAS No.: 1557348-34-1
• Molecular Formula: C₂₈H₂₉N₂OP
• Molecular Weight: 440.525
• Mol file: 1557348-34-1.mol

Synonyms:[(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine

Chemical Property of [(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine

There total 2 articles about [(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-N',N'-dimethyl-1,2-diphenylethane-1,2-diamine (320778-96-9) + Diphenylphosphinic chloride (1499-21-4) → [(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine (1557348-34-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2013.12.054

Reference yield:

2-[(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione (1233369-47-5) → [(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine (1557348-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 1 h / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With hydrazine hydrate; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.tet.2013.12.054

upstream raw materials:

(1R,2R)-N',N'-dimethyl-1,2-diphenylethane-1,2-diamine

Diphenylphosphinic chloride

2-[(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione