320778-96-9

Basic information

• Product Name: (1R,2R)- N',N'-diMethyl-1,2-diphenyl-1,2-EthanediaMine
• Synonyms: (1R,2R)-N',N'-Dimethyl-1,2-diphenyl-1,2-ethanediamine,99%e.e.
• CAS NO: 320778-96-9
• Molecular Formula: C₁₆H₂₀N₂
• Molecular Weight: 240.3434
• Mol File: 320778-96-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 323.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.052±0.06 g/cm3(Predicted)
• PKA: 9.62±0.10(Predicted)
• CAS DataBase Reference: (1R,2R)- N',N'-diMethyl-1,2-diphenyl-1,2-EthanediaMine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)- N',N'-diMethyl-1,2-diphenyl-1,2-EthanediaMine(320778-96-9)
• EPA Substance Registry System: (1R,2R)- N',N'-diMethyl-1,2-diphenyl-1,2-EthanediaMine(320778-96-9)

Safety Data

• Hazardous Substances Data: 320778-96-9(Hazardous Substances Data)

Usage

General Description

"(1R,2R)-N',N'-dimethyl-1,2-diphenyl-1,2-ethanediamine" is a chemical compound that belongs to the class of diamines. It is a chiral molecule, meaning it has non-superimposable mirror images. (1R,2R)- N',N'-diMethyl-1,2-diphenyl-1,2-EthanediaMine is commonly used as a chiral ligand in catalytic asymmetric synthesis, particularly in the production of pharmaceuticals and agrochemicals. It can also be employed as a ligand in metal-catalyzed hydrogenation and other organic synthesis reactions. Additionally, this compound has potential application in the field of coordination chemistry and organic synthesis due to its chiral nature and its ability to participate in enantioselective reactions.

Upstream product

• 1387581-28-3 2-[(1R,2R)-2-amino-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 1233369-47-5 2-[(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl]-2,3-dihydro-1H-isoindole-1,3-dione 

Downstream Products

• 172477-04-2 (1R,2R)-N₁,N₁,N₂-trimethyl-1,2-diphenylethane-1,2-diamine 
• 1370418-73-7 (S)-di-tert-butyl 2-{3-[(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl]thioureido}succinate 
• 1223105-89-2 C₂₈H₂₃F₆N₃O₂ 
• 1557348-34-1 [(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl](diphenylphosphoroso)amine 
• 1440198-60-6 C₃₁H₃₉N₃O₉S 
• 1440198-44-6 C₃₁H₃₉N₃O₉S 
• 1229652-46-3 C₂₃H₂₄N₄O₂S 
• 834917-24-7 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(dimethylamino)-1,2-diphenylethyl)thiourea 

Relevant articles and documents

Bio-inspired Water-Driven Catalytic Enantioselective Protonation

Catalytic enantioselective protonation of a prochiral carbanion in water is a common transformation in biological systems, but has been beyond the capability of synthetic chemists since unusually rapid movement of a proton in water leads to uncontrolled racemic protonation. Herein we show a crucial role of water, which enables a highly enantioselective glyoxalase I-mimic catalytic isomerization of hemithioacetals which proceeds via enantioselective protonation of an ene-diol intermediate. The use of on-water condition turns on this otherwise extremely unreactive catalytic reaction as a result of the strengthened hydrogen bonds of water molecules near the hydrophobic reaction mixture. Furthermore, under on-water conditions, especially under biphasic microfluidic on-water conditions, access of bulk water into the enantio-determining transition state is efficiently blocked, consequently enabling the enantioselective introduction of a highly ungovernable proton to a transient enediol intermediate, which mimics the action of enzymes.

Photoactivity hexahydroquinolinone and preparation method thereof

The invention discloses photoactivity hexahydroquinolinone and a preparation method thereof. The photoactivity hexahydroquinolinone is a diastereoisomer consisting of a compound shown as a formula I and a compound shown as a formula II, wherein a diastere

QSAR analysis of the catalytic asymmetric ethylation of ketone using physical steric parameters of chiral ligand substituents

We have demonstrated that a validated QSAR (quantitative structure-activity relationship) model can be constructed between sterimol steric parameters of the N-substituents of chiral 1,2-amino-phosphoramide ligands and the enantiomeric ratios of alcohol products produced in the asymmetric additions of diethylzinc to acetophenone, which is powerful for predicting the steric effects of ligand substituents on enantioselectivities and instructive for ligand optimization.