<2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus

Base Information

Chemical Name:<2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus
CAS No.:145484-36-2
Molecular Formula:C₃₁H₄₂NO₅P
Molecular Weight:539.652
Hs Code.:

Synonyms:<2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus

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Chemical Property of <2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus

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Technology Process of <2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus

There total 12 articles about <2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: 145454-62-2
(R)-2-(benzyloxy)-3-[(4-methoxybenzyl)oxy]propan-1-ol

: 145484-36-2
<2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus

Guidance literature:: With 1H-tetrazole; In 1,2-dichloro-ethane; acetonitrile; at 0 ℃;
DOI:10.1246/bcsj.65.2643

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 145484-36-2
<2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / (1S)-10-camphorsulfonic acid / tetrahydrofuran / 2.5 h / Heating

2: 1.) Zn(BH₄)2, 2.) TMSCl, 3.) imidazole

3: 93.8 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

4: 90.7 percent / 1H-tetrazole / 1,2-dichloro-ethane; acetonitrile / 0 °C

With 1H-imidazole; 1H-tetrazole; chloro-trimethyl-silane; zinc(II) tetrahydroborate; tetrabutyl ammonium fluoride; [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1246/bcsj.65.2643

Reference yield:

: 109786-74-5
(R)-3-(4-methoxybenzyloxy)propane-1,2-diol

: 145484-36-2
<2-O-benzyl-3-O-(p-methoxybenzyl)-sn-glycero(1)>benzyloxo(diisopropylamido)phosphorus

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / (1S)-10-camphorsulfonic acid / tetrahydrofuran / 2.5 h / Heating

2: 1.) Zn(BH₄)2, 2.) TMSCl, 3.) imidazole

3: 93.8 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

4: 90.7 percent / 1H-tetrazole / 1,2-dichloro-ethane; acetonitrile / 0 °C

With 1H-imidazole; 1H-tetrazole; chloro-trimethyl-silane; zinc(II) tetrahydroborate; tetrabutyl ammonium fluoride; [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1246/bcsj.65.2643