2H-Indol-2-one, 3-amino-1,3-dihydro-1-methyl-

Base Information

• Chemical Name: 2H-Indol-2-one, 3-amino-1,3-dihydro-1-methyl-
• CAS No.: 121974-35-4
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.191
• Mol file: 121974-35-4.mol

Synonyms:Oxindole,3-amino-1-methyl- (6CI)

Chemical Property of 2H-Indol-2-one, 3-amino-1,3-dihydro-1-methyl-

Chemical Property:

• Boiling Point: 356.6±42.0 °C(Predicted)
• PKA: 6.54±0.20(Predicted)
• PSA: 46.33000
• Density: 1.213±0.06 g/cm3(Predicted)
• LogP: 1.42810

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-1-methyl-1,3-dihydro-2H-indol-2-onehydrochlorideDihydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Indol-2-one, 3-amino-1,3-dihydro-1-methyl-

There total 5 articles about 2H-Indol-2-one, 3-amino-1,3-dihydro-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(hydroxyimino)-1-methylindolin-2-one → 3-amino-1-methylindolin-2-one (121974-35-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 10h; under 760.051 Torr;

DOI:10.1021/ol200724q

Reference yield:

1-methyl-1H-indole-2,3-dione 3-(O-methyloxime) (94268-48-1) → 3-amino-1-methylindolin-2-one (121974-35-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetonitrile; at 20 ℃; for 2h; atmospheric pressure;

DOI:10.1021/jo061541v

Reference yield:

C10H10N2O2 → 3-amino-1-methylindolin-2-one (121974-35-4)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In acetonitrile; at 20 ℃; for 6h; under 760.051 Torr;

DOI:10.1039/c9cc07346a

upstream raw materials:

(E)-3-(hydroxyimino)-1-methylindolin-2-one

1-methyl-1H-indole-2,3-dione 3-(O-methyloxime)

1-methyl-1H-indole-2,3-dione

Downstream raw materials:

(+)-5'-(4-fluorophenyl)-1,5'-dimethyl-2'-thioxospiro[indoline-3,4'-oxazolidin]-2-one

(+)-1,5'-dimethyl-2'-thioxo-5'-(3-(trifluoromethyl)phenyl)spiro[indoline-3,4'-oxazolidin]-2-one

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