α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol

Base Information

• Chemical Name: α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol
• CAS No.: 285552-88-7
• Molecular Formula: C₁₄H₂₁N₅O₂
• Molecular Weight: 291.353
• Mol file: 285552-88-7.mol

Synonyms:α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol

Chemical Property of α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol

There total 1 articles about α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 1-azido-3-(p-toluenesulfonyloxy)propan-2-ol (168431-73-0) → α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol (285552-88-7)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 36h;

DOI:10.1016/S0968-0896(00)00151-6 DOI:10.1021/jm9905918

Reference yield: 93.0%

α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol (285552-88-7) → α-(aminomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol (217170-70-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; at 20 ℃; for 16h; under 2585.74 Torr;

DOI:10.1016/S0968-0896(00)00151-6

Reference yield:

α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol (285552-88-7) → 2-(3-fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid {2-hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-amide

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / H₂; HCl / 10percent Pd/C / methanol / 16 h / 20 °C / 2585.81 Torr

2: 47 percent / N,N-diisopropylethylamine; HATU / CH₂Cl₂ / 18 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 10percent Pd/C; In methanol; dichloromethane; 1: Reduction / 2: Acylation;

DOI:10.1021/jm9905918

upstream raw materials:

1-(2-Methoxyphenyl)piperazine

1-azido-3-(p-toluenesulfonyloxy)propan-2-ol

Downstream raw materials:

α-(aminomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol