1-Piperazineethanol, alpha-(aminomethyl)-4-(2-methoxyphenyl)-

Base Information

Chemical Name:1-Piperazineethanol, alpha-(aminomethyl)-4-(2-methoxyphenyl)-
CAS No.:217170-70-2
Molecular Formula:C₁₄H₂₃N₃O₂
Molecular Weight:265.356
Hs Code.:
DSSTox Substance ID:DTXSID901203632

Synonyms:217170-70-2;1-Piperazineethanol, alpha-(aminomethyl)-4-(2-methoxyphenyl)-;SCHEMBL8483868;DTXSID901203632;AKOS000172023;alpha-(Aminomethyl)-4-(2-methoxyphenyl)-1-piperazineethanol

Suppliers and Price of 1-Piperazineethanol, alpha-(aminomethyl)-4-(2-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperazineethanol, alpha-(aminomethyl)-4-(2-methoxyphenyl)-

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:265.17902698
Heavy Atom Count:19
Complexity:257

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1N2CCN(CC2)CC(CN)O

Technology Process of 1-Piperazineethanol, alpha-(aminomethyl)-4-(2-methoxyphenyl)-

There total 3 articles about 1-Piperazineethanol, alpha-(aminomethyl)-4-(2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 285552-88-7
α-(azidomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol

: 217170-70-2
α-(aminomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; at 20 ℃; for 16h; under 2585.74 Torr;
DOI:10.1016/S0968-0896(00)00151-6

Reference yield: 92.0%

: 217170-69-9
1-phthaloylamino-3-[4-(2-methoxyphenyl)piperazin-1-yl]propanol

: 217170-70-2
α-(aminomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol

Guidance literature:: With hydrazine hydrate; In ethanol; for 5h;
DOI:10.1016/S0040-4039(98)01905-4

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 217170-70-2
α-(aminomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 1-methyl-pyrrolidin-2-one / 36 h / 100 °C

2: 93 percent / H₂; HCl / 10percent Pd/C / methanol / 16 h / 20 °C / 2585.81 Torr

With hydrogenchloride; hydrogen; 10percent Pd/C; In 1-methyl-pyrrolidin-2-one; methanol; 1: Substitution / 2: Reduction;
DOI:10.1021/jm9905918