decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

Base Information

Chemical Name:decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide
CAS No.:400723-18-4
Molecular Formula:C₂₆H₃₆N₂O₄
Molecular Weight:440.583
Hs Code.:

Synonyms:decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

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Chemical Property of decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

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Technology Process of decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

There total 4 articles about decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 22221-61-0
N-decanoyl-D-phenylalanine

: 104333-09-7
4-amino-2-hydroxymethylphenol

: 400723-18-4
decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/S0968-0896(01)00165-1

Reference yield:

: 42753-75-3
methyl 5-amino-2-hydroxybenzoate

: 400723-18-4
decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / lithium aluminium hydride / tetrahydrofuran

2: 39 percent / 1-hydroxybenzotriazole hydrate; 1,3-dicyclohexylcarbodiimide / dimethylformamide / 0 - 20 °C

With lithium aluminium tetrahydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00165-1

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 400723-18-4
decanoic acid (2-phenyl-1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / sodium bicarbonate / H₂O; tetrahydrofuran / 18 h / 20 °C

2: 39 percent / 1-hydroxybenzotriazole hydrate; 1,3-dicyclohexylcarbodiimide / dimethylformamide / 0 - 20 °C

With sodium hydrogencarbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: Schotten-Baumann reaction;
DOI:10.1016/S0968-0896(01)00165-1