ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate

Base Information

• Chemical Name: ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate
• CAS No.: 1644190-84-0
• Molecular Formula: C₂₂H₁₈O₃
• Molecular Weight: 330.383
• Mol file: 1644190-84-0.mol

Synonyms:ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate

Chemical Property of ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate

There total 2 articles about ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl acetoacetate (141-97-9) + phenylacetylene (536-74-3) → ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate (1644190-84-0)

Guidance literature:

With [2,2]bipyridinyl; tetrachloroauric(III) acid hydrate; [bis(acetoxy)iodo]benzene; potassium acetate; In toluene; at 40 ℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/anie.201402475

Reference yield: 46.0%

ethyl acetoacetate (141-97-9) + gold(I) phenylacetylide (34679-27-1) → ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate (1644190-84-0)

Guidance literature:

With [2,2]bipyridinyl; [bis(acetoxy)iodo]benzene; potassium acetate; In toluene; at 40 ℃; for 24h; Inert atmosphere; Sealed tube; Schlenk technique;

DOI:10.1002/anie.201402475

Reference yield: 90.0%

ethyl 2-methyl-5-phenyl-4-(phenylethynyl)furan-3-carboxylate (1644190-84-0) → ethyl 2-methyl-4-phenethyl-5-phenylfuran-3-carboxylate (1644191-20-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 10h; under 760.051 Torr; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201402475

upstream raw materials:

ethyl acetoacetate

phenylacetylene

gold(I) phenylacetylide

Downstream raw materials:

ethyl 2-methyl-4-phenethyl-5-phenylfuran-3-carboxylate

(Z)-ethyl 2-methyl-5-phenyl-4-styrylfuran-3-carboxylate