Technology Process of 2-ethoxy-5-isobutyl-3-(3,4-dimethoxyphenyl)-6-(1H-1,2,3-triazol-4-yl)pyrazine
There total 7 articles about 2-ethoxy-5-isobutyl-3-(3,4-dimethoxyphenyl)-6-(1H-1,2,3-triazol-4-yl)pyrazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper; copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine;
In
tetrahydrofuran; water; isopropyl alcohol;
at 90 ℃;
for 0.333333h;
regioselective reaction;
Microwave irradiation;
DOI:10.1055/s-0031-1289714
- Guidance literature:
-
With
trimethylsilylazide; copper; copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine;
In
tetrahydrofuran; water; isopropyl alcohol;
at 90 ℃;
for 0.333333h;
Microwave irradiation;
DOI:10.1021/jo102089h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Lawessons reagent / toluene / 4 h / Reflux
2.1: iodine / dichloromethane / 0.25 h / 80 °C / Microwave irradiation
3.1: tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate / tetrahydrofuran / 1 h / 120 °C / Microwave irradiation
4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; tetra-(n-butyl)ammonium iodide; triethylamine / N,N-dimethyl-formamide / 0.33 h / 80 °C / Microwave irradiation
4.2: 20 °C
5.1: trimethylsilylazide; copper; copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / tetrahydrofuran; water; isopropyl alcohol / 0.33 h / 90 °C / Microwave irradiation
With
Lawessons reagent; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate; trimethylsilylazide; iodine; tetra-(n-butyl)ammonium iodide; copper; copper(II) sulfate; triethylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
3.1: Liebeskind-Srogl coupling / 4.1: Sonogashira coupling;
DOI:10.1021/jo102089h
