(2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

Base Information

Chemical Name:(2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine
CAS No.:178357-86-3
Molecular Formula:C₁₆H₂₀FN₃O₄
Molecular Weight:337.351
Hs Code.:

Synonyms:(2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

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Technology Process of (2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

There total 1 articles about (2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 131858-37-2
4-(bromomethyl)-2-fluoro-1-nitrobenzene

: 178357-86-3
(2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

Guidance literature:: Multistep reaction;
DOI:10.1021/jo9604144

Reference yield: 92.0%

: 178357-86-3
(2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

: 178208-42-9
(R)-3-fluoro-4-nitrophenylalanine methyl ester

Guidance literature:: With hydrogenchloride; sodium hydrogencarbonate; In water;
DOI:10.1021/jo961346o

Reference yield:

: 178357-86-3
(2R,5S)-2-(3-Fluoro-4-nitro-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

: 178208-46-3
3-fluoro-4-nitro-N-[N-(tert-butyloxycarbonyl)-N-methyl-D-tyrosyl]-D-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 0.25N HCl, NaHCO₃ / H₂O

2: 4 percent / tetrahydrofuran / 4 h / 25 °C

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; water;
DOI:10.1021/jo961346o