6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

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Chemical Name:6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
CAS No.:1354200-36-4
Molecular Formula:C₂₀H₁₃F₆N₅O₃
Molecular Weight:485.345
Hs Code.:

Synonyms:6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

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Chemical Property of 6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

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Technology Process of 6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

There total 4 articles about 6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370524-39-2
2-(2-hydroxyethyl)-6-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

: 69034-12-4
2-chloro-5-(trifluoromethyl)pyrimidine

: 1354200-36-4
6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 110 ℃; Inert atmosphere;

Reference yield:

: 425702-91-6
6-bromo-[1,2,4]triazole[4,3-a]pyridine-3(2H)-one

: 1354200-36-4
6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / isopropyl alcohol; toluene; water / 72 h / 95 °C / sealed vessel; Inert atmosphere

2: potassium carbonate / ISOPROPYLAMIDE / 110 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 110 °C / Inert atmosphere

With sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil;

Reference yield:

: 77992-44-0
5-bromo-2-hydrazinylpyridine

: 1354200-36-4
6-(4-(trifluoromethoxy)phenyl)-2-(2-(5-(trifluoromethyl)pyrimidin-2-yloxy)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 2 h / Reflux; Inert atmosphere

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / isopropyl alcohol; toluene; water / 72 h / 95 °C / sealed vessel; Inert atmosphere

3: potassium carbonate / ISOPROPYLAMIDE / 110 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 110 °C / Inert atmosphere

With sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile; mineral oil;