77992-44-0

Basic information

• Product Name: 5-BROMO-2-HYDRAZINOPYRIDINE
• Synonyms: 5-BROMO-2-HYDRAZINOPYRIDINE;5-BROMO-2-HYDRAZINYLPYRIDINE;2-Hydrazino-5-bromopyridine;5-Bromo-2-hydrazinopyridine 97%;N-(5-Bromo-2-pyridyl)hydrazine;1-(5-bromopyridin-2-yl)hydrazine;5-broMo-2-hydrazinylpyriMidine;5-broMo-2-hydrazinylidene-1,2-dihydropyridine
• CAS NO: 77992-44-0
• Molecular Formula: C₅H₆BrN₃
• Molecular Weight: 188.03
• Product Categories: blocks;Bromides;Pyridines;Heterocyclic Compounds;Organohalides;Pyridine;amine|alkyl bromide
• Mol File: 77992-44-0.mol
• Article Data: 43

Chemical Properties

• Melting Point: 132.0 to 136.0 °C
• Boiling Point: 305.711 °C at 760 mmHg
• Flash Point: 138.689 °C
• Appearance: /
• Density: 1.783 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.695
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.97±0.70(Predicted)
• CAS DataBase Reference: 5-BROMO-2-HYDRAZINOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-HYDRAZINOPYRIDINE(77992-44-0)
• EPA Substance Registry System: 5-BROMO-2-HYDRAZINOPYRIDINE(77992-44-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-37/38-41
• Safety Statements: 26-36-45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 77992-44-0(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-hyrdazinopyridine is a chemical compound with the molecular formula C5H6BrN3. Based on its structural configuration, it belongs to the class of organic compounds known as aminopyridines and derivatives. These are organic compounds containing an amino group attached to a pyridine ring. 5-Bromo-2-hyrdazinopyridine is primarily used in the field of organic synthesis as a building block or reagent due to its potential for various chemical transformations. Its chemical properties make it suitable for research and development applications in chemical synthesis or pharmaceuticals. It is less common in consumer applications due to its specialized nature. The substance is usually available as a solid. However, its safety and toxicity are often context-specific and may require handling by trained personnel.

InChI:InChI=1/C5H6BrN3/c6-4-1-2-5(9-7)8-3-4/h1-3H,7H2,(H,8,9)

Upstream product

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Downstream Products

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• 664990-45-8 5-bromo-3-(4-methoxyphenyl)-2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 664991-65-5 N-(5-{2-[(5-bromopyridin-2-yl)-hydrazono]-2-phenylethyl}-furan-2-ylmethyl)-acetamide 
• 1026740-75-9 methyl-5-(5-bromo-3-phenyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-pyrrole-2-carboxylate 
• 664990-64-1 5-bromo-3-phenyl-2-(1H-pyrrol-3-yl)-1H-pyrrolo[2,3-b]pyridine 
• 664990-65-2 5-bromo-3-phenyl-2-(1,3-oxazol-2-yl)-1H-pyrrolo[2,3-b]pyridine 
• 876299-48-8 2-(benzyloxy)benzaldehyde (5-bromopyridin-2-yl)hydrazone 
• 876372-92-8 methyl 4-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)benzoate 
• 1093092-64-8 6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-thiol 
• 1293385-64-4 5-bromo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine 
• 1293979-76-6 6-bromo-3,3-difluoro-2-(4-(thiophen-2-yl)benzylidene)-2,3-dihydro-[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide 

Relevant articles and documents

Dual Reactivity of 1,2,3,4-Tetrazole: Manganese-Catalyzed Click Reaction and Denitrogenative Annulation

A general catalytic method using a Mn-porphyrin-based catalytic system is reported that enables two different reactions (click reaction and denitrogenative annulation) and affords two different classes of nitrogen heterocycles, 1,5-disubstituted 1,2,3-triazoles (with a pyridyl motif) and 1,2,4-triazolo-pyridines. Mechanistic investigations suggest that although the click reaction likely proceeds through an ionic mechanism, which is different from the traditional click reaction, the denitrogenative annulation reaction likely proceeds via an electrophilic metallonitrene intermediate rather than a metalloradical intermediate. Collectively, this method is highly efficient and offers several advantages over other methods. For example, this method excludes a multi-step synthesis of the N-heterocyclic molecules described and produces only environmentally benign N2 gas a by-product.

CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION

Compounds of Formula I, Formula II, and Formula III and the pharmaceutically acceptable salts thereof are disclosed. The variables X, a, b, c, d, R1-4, R10-15 and R17-22 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving M2 phenotype of macrophages. Pharmaceutical compositions containing compounds of Formula I or Formula II or Formula III and methods of treatment comprising administering compounds of Formula I and Formula II and Formula III are also disclosed.

TRIAZOLOPYRIDIN-3-ONES OR THEIR SALTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present technology provides triazolopyridin-3-ones or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and uses thereof. The triazolopyridin-3-ones or their pharmaceutically acceptable salts exhibit inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).