4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Base Information

Chemical Name:4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione
CAS No.:120040-34-8
Molecular Formula:C₂₃H₂₈N₂O₅
Molecular Weight:412.486
Hs Code.:

Synonyms:4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

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Chemical Property of 4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

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Technology Process of 4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

There total 5 articles about 4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 120040-33-7
(Z)-4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 120040-34-8
4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 72h; under 760 Torr;
DOI:10.1248/cpb.36.2607

Reference yield:

: 100-39-0
benzyl bromide

: 120040-34-8
4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 1 h

2: 80.7 percent / hydrazine hydrate / dimethylformamide / 1 h / 25 °C

3: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 1 h

4: 72 percent / hydrogen / 10percent palladium on carbon / ethanol / 72 h / 760 Torr

With hydrogen; sodium hydride; hydrazine hydrate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2607

Reference yield:

: 113296-74-5
(Z)-1-acetyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 120040-34-8
4-benzyl-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 1 h

2: 80.7 percent / hydrazine hydrate / dimethylformamide / 1 h / 25 °C

3: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 1 h

4: 72 percent / hydrogen / 10percent palladium on carbon / ethanol / 72 h / 760 Torr

With hydrogen; sodium hydride; hydrazine hydrate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2607