N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide

Base Information

Chemical Name:N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide
CAS No.:1435685-06-5
Molecular Formula:C₂₄H₃₃N₃O₂S
Molecular Weight:427.611
Hs Code.:

Synonyms:N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide

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Chemical Property of N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide

Chemical Property:

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Technology Process of N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide

There total 6 articles about N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 13205-48-6,562836-64-0
4-(methylthio)benzoic acid

: 1435684-52-8
4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butan-1-amine

: 1435685-06-5
N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 15h;
DOI:10.1016/j.bmc.2013.03.074

Reference yield:

: 112275-50-0
tert-butyl 1,4-diazepine-1-carboxylate

: 1435685-06-5
N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; potassium tert-butylate / toluene / 21 h / 110 °C

2: trifluoroacetic acid / water / 20 °C

3: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

4: hydrazine hydrate / ethanol / 2 h / Reflux

5: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 15 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.03.074

Reference yield:

: tert-Butyl 4-(2-methoxyphenyl)-1,4-diazepane-1-carboxylate

: 1435685-06-5
N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / water / 20 °C

2: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

3: hydrazine hydrate / ethanol / 2 h / Reflux

4: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 15 h / 0 - 20 °C

With potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2013.03.074