1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

Base Information

Chemical Name:1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine
CAS No.:1426408-78-7
Molecular Formula:C₁₉H₁₆F₅N₃O
Molecular Weight:397.348
Hs Code.:

Synonyms:1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

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Chemical Property of 1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

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Technology Process of 1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

There total 5 articles about 1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426408-69-6
2-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1426408-77-6
1-(2-fluorophenyl)-5-iodo-1H-pyrazol-3-ylamine

: 1426408-78-7
1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

Guidance literature:: With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; at 105 ℃; for 4h;

Reference yield:

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 1426408-78-7
1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

3.1: tricyclohexylphosphine; palladium diacetate; potassium carbonate / water; 1,4-dioxane / 4 h / 105 °C

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; palladium diacetate; sodium hydride; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling / 3.1: |Suzuki Coupling;

Reference yield:

: 1426408-68-5
1-fluoro-3-((R)-2,2,2-trifluoro-1-methylethoxymethyl)benzene

: 1426408-78-7
1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

2: tricyclohexylphosphine; palladium diacetate; potassium carbonate / water; 1,4-dioxane / 4 h / 105 °C

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; palladium diacetate; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; water; 1: |Suzuki Coupling / 2: |Suzuki Coupling;