(2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester

Base Information

Chemical Name:(2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester
CAS No.:109838-78-0
Molecular Formula:C₁₅H₁₇NO₅
Molecular Weight:291.304
Hs Code.:

Synonyms:(2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester

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Chemical Property of (2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of (2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester

There total 4 articles about (2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109838-77-9
5,5-Diethoxycarbonyl-1-methyl-4-phenyl-pyrrolidin-2-one

: 109838-78-0
(2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester

Guidance literature:: With barium dihydroxide; In ethanol; at 70 ℃; for 0.333333h; Yield given;
DOI:10.1021/jo00228a037

Reference yield:

: 13992-75-1
5,5-Diethoxycarbonyl-4-phenylpyrrolidin-2-one

: 109838-78-0
(2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 2.) DMF, RT, 1 h

2: aq. Ba(OH)2 / ethanol / 0.33 h / 70 °C

With barium dihydroxide; sodium hydride; In ethanol;
DOI:10.1021/jo00228a037

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 109838-78-0
(2S,3R)-1-Methyl-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) EtONa / 1.) EtOH, RT, 2.) EtOH, reflux, 24 h

2: 1.) NaH / 1.) DMF, RT, 2.) DMF, RT, 1 h

3: aq. Ba(OH)2 / ethanol / 0.33 h / 70 °C

With barium dihydroxide; sodium ethanolate; sodium hydride; In ethanol;
DOI:10.1021/jo00228a037