13992-75-1

Basic information

• Product Name: 4-phenyl-5,5-dicarbethoxy-2-pyrrolidinone
• Synonyms: 4-phenyl-5,5-dicarbethoxy-2-pyrrolidinone
• CAS NO: 13992-75-1
• Molecular Formula: C₁₆H₁₉NO₅
• Molecular Weight: 0
• Mol File: 13992-75-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 452.5°Cat760mmHg
• Flash Point: 227.4°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 2.24E-08mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 4-phenyl-5,5-dicarbethoxy-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-5,5-dicarbethoxy-2-pyrrolidinone(13992-75-1)
• EPA Substance Registry System: 4-phenyl-5,5-dicarbethoxy-2-pyrrolidinone(13992-75-1)

Safety Data

• Hazardous Substances Data: 13992-75-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H19NO5/c1-3-21-14(19)16(15(20)22-4-2)12(10-13(18)17-16)11-8-6-5-7-9-11/h5-9,12H,3-4,10H2,1-2H3,(H,17,18)

Upstream product

• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 4192-77-2 ethyl cinnamate 

Downstream Products

• 109838-79-1 (+/-)-(4R^*,5R^*)-5-(ethoxycarbonyl)-1-methyl-4-phenylpyrrolidin-2-one 
• 109838-79-1 (+/-)-(4R^*,5S^*)-5-(ethoxycarbonyl)-1-methyl-4-phenylpyrrolidin-2-one 
• 1338928-99-6 C₂₀H₂₁NO₄ 
• 1338929-01-3 C₁₂H₁₅NO₃ 
• 1338929-00-2 C₁₂H₁₅NO₃ 
• 1338929-05-7 C₁₉H₂₁NO₃ 
• 1338929-04-6 C₁₉H₂₁NO₃ 
• 1338929-07-9 C₂₉H₂₉NO₆ 
• 1338929-06-8 C₂₉H₂₉NO₆ 
• 608128-73-0 (3R,4S,5S,6S)-epi-cis-clausenamide 
• 124687-29-2 (+/-)-cis-5-(hydroxymethyl)-4-phenyl-2-pyrrolidinone 
• 124687-30-5 (+/-)-trans-5-(hydroxymethyl)-4-phenyl-2-pyrrolidinone 
• 55137-97-8 4-phenyl-5-carboxy-2-pyrrolidinone 
• 14226-05-2 4-phenyl-5,5-dicarboxy-2-pyrrolidinone 

Relevant articles and documents

Preparation of 4- and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide

4- and 6-desphenyl analogues of (-)-clausenamide, 6 and 7, were prepared in optical active form from commercially available d-pyroglutamic acid and the known racemic pyrrolidinone 13, respectively. In order to confirm the absolute stereochemistry of (+)-

Process for the preparation of gamma-butyrolactams

A process for the preparation of a C(3)-C(4)-transconfigurated γ-butyrolactam of the formula (I) STR1 in which R1 represents hydrogen or alkyl, aryl or aralkyl with in each case up to 10 carbon atoms and R2 and R3 are iden

Diastereoselective and Enantioselective Total Synthesis of the Hepatoprotective Agent Clausenamide

The diastereoselective total synthesis of the naturally ocurring hepatoprotective agent clausenamide (3-hydroxy-5-(α-hydroxybenzyl)-1-methyl-4-phenylpyrrolidin-2-one) is described, starting from ethyl cinnamate and diethyl acetamidomalonate.The enantioselective total synthesis of optically pure (+)-clausenamide is presented.The synthesis is based on a novel method for the preparation of optically pure (2S,3S)-3-phenylglutamic acid.