methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate

Base Information

Chemical Name:methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate
CAS No.:273936-72-4
Molecular Formula:C₁₆H₂₆O₄
Molecular Weight:282.38
Hs Code.:

Synonyms:methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate

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Chemical Property of methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate

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Technology Process of methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate

There total 4 articles about methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 273936-71-3
3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoic acid

: 273936-72-4
methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate

Guidance literature:: In diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1021/ja9939284

Reference yield:

: 273936-70-2
3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanal

: 273936-72-4
methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / NaClO₂; 2-methyl-2-butene; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

2: 88 percent / diethyl ether / 0.5 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In diethyl ether; water; tert-butyl alcohol; 1: Oxidation / 2: Esterification;
DOI:10.1021/ja9939284

Reference yield:

: 273936-69-9
3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}-1-propanol

: 273936-72-4
methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

2: 83 percent / NaClO₂; 2-methyl-2-butene; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

3: 88 percent / diethyl ether / 0.5 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; water; tert-butyl alcohol; 1: Swern oxidation / 2: Oxidation / 3: Esterification;
DOI:10.1021/ja9939284