4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

Base Information

Chemical Name:4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine
CAS No.:342630-74-4
Molecular Formula:C₃₆H₆₀N₂O₈SSi₂
Molecular Weight:737.118
Hs Code.:

Synonyms:4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

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Chemical Property of 4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

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Technology Process of 4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

There total 1 articles about 4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 98495-56-8
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

: 342630-74-4
4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1055/s-2001-12355

Reference yield:

: 342630-74-4
4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

: 342630-78-8
5'-O-(4,4'-Dimethoxytrityl)-N⁴-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / CH₂Cl₂ / 18 h / Heating

2: 95 percent / TBAF / tetrahydrofuran / 18 h / 20 °C

3: 72 percent / pyridine / 3 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2001-12355

Reference yield:

: 342630-74-4
4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

: 5'-O-(4,4'-Dimethoxytrityl)-N⁴-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / CH₂Cl₂ / 18 h / Heating

2: 95 percent / TBAF / tetrahydrofuran / 18 h / 20 °C

3: 72 percent / pyridine / 3 h / 20 °C

4: 83 percent / DIPEA / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2001-12355