Technology Process of 3'-N-debenzoyl-3'-N-Troc-7-Troc-paclitaxel
There total 7 articles about 3'-N-debenzoyl-3'-N-Troc-7-Troc-paclitaxel which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol;
at 20 ℃;
for 24h;
DOI:10.1021/jm034112n
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 98 percent / DMAP; DCC / toluene; CH2Cl2 / 3 h / 20 °C
2: 94 percent / p-toluene sulfonic acid / methanol / 24 h / 20 °C
With
dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide;
In
methanol; dichloromethane; toluene;
DOI:10.1021/jm034112n
- Guidance literature:
-
Multi-step reaction with 6 steps
1: aq. NaOH; aq. NaHCO3 / dioxane / 1 h / 20 °C
2: 726 mg / SOCl2 / 14 h / 0 - 20 °C
3: 92 percent / pyridinium p-toluenesulfonate / toluene / 0.5 h / Heating
4: 99 percent / aq. KOH / methanol / 0.5 h / 20 °C
5: 98 percent / DMAP; DCC / toluene; CH2Cl2 / 3 h / 20 °C
6: 94 percent / p-toluene sulfonic acid / methanol / 24 h / 20 °C
With
dmap; potassium hydroxide; sodium hydroxide; thionyl chloride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide;
In
1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1021/jm034112n
