N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide

Base Information

• Chemical Name: N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide
• CAS No.: 1392150-34-3
• Molecular Formula: C₁₂H₉F₂N₅O₂S
• Molecular Weight: 325.299
• Mol file: 1392150-34-3.mol

Synonyms:N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide

Chemical Property of N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide

There total 2 articles about N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(6-chloro-5-cyanopyridin-3-yl)-3,5-difluorobenzene-sulfonamide. (1392150-35-4) → N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide (1392150-34-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 100 ℃; for 20h;

Reference yield:

5-amino-2-chloro-3-pyridinecarbonitrile (13600-46-9) + 3,5-difluorobenzenesulfonyl chloride (210532-25-5) → N-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-3,5-difluorobenzene sulfonamide (1392150-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 15 h / 20 - 70 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 20 h / 100 °C / Inert atmosphere

With pyridine; hydrazine hydrate; In tetrahydrofuran; ethanol;

upstream raw materials:

5-amino-2-chloro-3-pyridinecarbonitrile

3,5-difluorobenzenesulfonyl chloride

N-(6-chloro-5-cyanopyridin-3-yl)-3,5-difluorobenzene-sulfonamide.