Technology Process of (1R,2S)-1-(3,4-dimethoxyphenyl)-2-O-(2-methoxy-4-omegahydroxypropylphenyl)propane-1,3-diol
There total 7 articles about (1R,2S)-1-(3,4-dimethoxyphenyl)-2-O-(2-methoxy-4-omegahydroxypropylphenyl)propane-1,3-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
ethyl acetate;
at 20 ℃;
for 1h;
under 3800.26 Torr;
DOI:10.1039/c6ra22026f
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride; benzyl chloride / tetrahydrofuran / 0 - 20 °C
2.1: potassium carbonate; potassium iodide / acetone / 0.25 h / 20 °C
2.2: 20 °C
3.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C
3.2: 2 h / 0 - 20 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
4.2: 1 h / Inert atmosphere
5.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
7.1: palladium on activated charcoal; hydrogen / ethyl acetate / 1 h / 20 °C / 3800.26 Torr
With
1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; benzyl chloride; potassium iodide; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1039/c6ra22026f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate; potassium iodide / acetone / 0.25 h / 20 °C
1.2: 20 °C
2.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C
2.2: 2 h / 0 - 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
3.2: 1 h / Inert atmosphere
4.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
6.1: palladium on activated charcoal; hydrogen / ethyl acetate / 1 h / 20 °C / 3800.26 Torr
With
1H-imidazole; sodium tetrahydroborate; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; potassium iodide; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1039/c6ra22026f
