(R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Base Information

Chemical Name:(R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate
CAS No.:1371609-34-5
Molecular Formula:C₂₀H₁₆F₃N₃O₃
Molecular Weight:403.361
Hs Code.:

Synonyms:(R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

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Technology Process of (R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

There total 6 articles about (R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 191165-13-6
4-bromo-2-(trifluoromethyl)benzonitrile

: 1254700-17-8
benzyl (4R)-1-methyl-2-oxo-4-imidazolidinecarboxylate

: 1371609-34-5
(R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 5h; Inert atmosphere;

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1371609-34-5
(R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopentyl nitrite / acetonitrile / 0.5 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

With caesium carbonate; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; acetonitrile;

Reference yield:

: 1033726-49-6
benzyl 3-tert-butyloxycarbonyl-imidazolidin-2-one-4(R)-carboxylate

: 1371609-34-5
(R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

3.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

With sodium hydride; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; mineral oil;