2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile

Base Information

Chemical Name:2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile
CAS No.:1371609-37-8
Molecular Formula:C₁₃H₁₂F₃N₃O₂
Molecular Weight:299.252
Hs Code.:

Synonyms:2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile

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Chemical Property of 2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile

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Technology Process of 2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile

There total 6 articles about 2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1371609-36-7
(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

: 1371609-37-8
2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile

Guidance literature:: With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 6h;

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1371609-37-8
2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopentyl nitrite / acetonitrile / 0.5 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

4.1: potassium hydroxide / diethyl ether

4.2: 1 h / 0 - 20 °C / Inert atmosphere

5.1: ethanol; sodium tetrahydroborate / 6 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; hydrogen; caesium carbonate; potassium hydroxide; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; diethyl ether; acetonitrile;

Reference yield:

: 1254700-17-8
benzyl (4R)-1-methyl-2-oxo-4-imidazolidinecarboxylate

: 1371609-37-8
2-(trifluoromethyl)-4-((R)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

3.1: potassium hydroxide / diethyl ether

3.2: 1 h / 0 - 20 °C / Inert atmosphere

4.1: ethanol; sodium tetrahydroborate / 6 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; hydrogen; caesium carbonate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; diethyl ether;