N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide

Base Information

Chemical Name:N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide
CAS No.:1303445-72-8
Molecular Formula:C₂₃H₁₈F₆N₂O₂
Molecular Weight:468.399
Hs Code.:

Synonyms:N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide

Chemical Property:

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Technology Process of N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide

There total 5 articles about N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1303445-67-1
N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide

: 1303445-72-8
N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2011.02.031

Reference yield:

: 1256643-39-6
2-methyl-4-phenylnicotinic acid

: 1303445-72-8
N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / Reflux

2: triethylamine / dichloromethane / 1 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

With thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform;
DOI:10.1016/j.bmc.2011.02.031

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1303445-72-8
N-[3,5-bis(trifluoromethyl)benzyl]-N,2-dimethyl-4-phenylnicotinamide 1-oxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine / N,N-dimethyl-formamide / 1 h / Reflux

2.1: sodium hydroxide / ethanol / 6 h / Reflux

2.2: 0 - 5 °C / pH 5 - 6

3.1: thionyl chloride / 3 h / Reflux

4.1: triethylamine / dichloromethane / 1 h / Reflux

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

With piperidine; thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.02.031