(R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

Base Information

• Chemical Name: (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester
• CAS No.: 956320-18-6
• Molecular Formula: C₂₆H₃₉Cl₂F₃N₂O₅SSi
• Molecular Weight: 647.659
• Mol file: 956320-18-6.mol

Synonyms:(R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

Chemical Property of (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

There total 9 articles about (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (956320-31-3) + trifluoromethylsulfonic anhydride (358-23-6) → (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester (956320-18-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester (956320-18-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: acetic acid; sodium nitrite / water / 5.83 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Heating / reflux

2.2: 0.17 h / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

4.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

5.1: hydrogen / palladium hydroxide on carbon / ethanol / 2 h / 20 °C / 1034.32 Torr

6.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; sodium nitrite; palladium hydroxide on carbon; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; water;

Reference yield:

(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one (956320-30-2) → (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester (956320-18-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 12 h / 0 - 20 °C

2: hydrogen / palladium hydroxide on carbon / ethanol / 2 h / 20 °C / 1034.32 Torr

3: pyridine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; hydrogen; palladium hydroxide on carbon; In ethanol; dichloromethane;

upstream raw materials:

(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

trifluoromethylsulfonic anhydride

4-HYDROXYPIPERIDINE

(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

Downstream raw materials:

(R)-3',5'-dichloro-3-fluoro-4'-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carbonitrile

(R)-3',5'-dichloro-4'-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid methyl ester

(R)-3-(3,5-dichloro-4'-trifluoromethyl-biphenyl-4-ylmethyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

(R)-3-(3,5-dichloro-4'-methanesulfonyl-biphenyl-4-ylmethyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one