(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one
CAS No.:956320-31-3
Molecular Formula:C₂₅H₄₀Cl₂N₂O₃Si
Molecular Weight:515.596
Hs Code.:

Synonyms:(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

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Chemical Property of (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

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Technology Process of (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

There total 8 articles about (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 956320-29-9
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

: 956320-31-3
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Guidance literature:: With hydrogen; palladium hydroxide on carbon; In ethanol; at 20 ℃; for 2h; under 1034.32 Torr;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 956320-31-3
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; sodium nitrite / water / 5.83 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Heating / reflux

2.2: 0.17 h / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

4.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

5.1: hydrogen / palladium hydroxide on carbon / ethanol / 2 h / 20 °C / 1034.32 Torr

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; sodium nitrite; palladium hydroxide on carbon; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; water;

Reference yield:

: 956320-30-2
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

: 956320-31-3
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 12 h / 0 - 20 °C

2: hydrogen / palladium hydroxide on carbon / ethanol / 2 h / 20 °C / 1034.32 Torr

With pyridine; hydrogen; palladium hydroxide on carbon; In ethanol; dichloromethane;