1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite

Base Information

Chemical Name:1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite
CAS No.:1352749-71-3
Molecular Formula:C₄₁H₅₁N₄O₉P
Molecular Weight:774.851
Hs Code.:

Synonyms:1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite

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Chemical Property of 1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite

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Technology Process of 1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite

There total 7 articles about 1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1352749-69-9
1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1352749-71-3
1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1039/c1ob06148h

Reference yield:

: 1352749-67-7
1-[3-O-(tert-butyldimethylsilyl)-2-deoxy-4-methoxy-α-L-threo-pentofuranosyl]thymine

: 1352749-71-3
1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; triethylamine / methanol

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1039/c1ob06148h

Reference yield:

: C₃₈H₄₈N₂O₈Si

: 1352749-71-3
1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine-3'-O-(O-(2-cyanoethyl)-N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1039/c1ob06148h