1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine

Base Information

Chemical Name:1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine
CAS No.:1352749-69-9
Molecular Formula:C₃₂H₃₄N₂O₈
Molecular Weight:574.631
Hs Code.:

Synonyms:1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine

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Chemical Property of 1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine

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Technology Process of 1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine

There total 6 articles about 1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₄₈N₂O₈Si

: 1352749-69-9
1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1039/c1ob06148h

Reference yield:

: 1352749-67-7
1-[3-O-(tert-butyldimethylsilyl)-2-deoxy-4-methoxy-α-L-threo-pentofuranosyl]thymine

: 1352749-69-9
1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; triethylamine / methanol

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1039/c1ob06148h

Reference yield:

: 25953-14-4,94892-66-7
1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: 1352749-69-9
1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4'-methoxy-α-L-threo-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / methanol / 8 h / Reflux

2: pyridine; 1H-imidazole / 8 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / 5 h / 20 °C

4: pyridine; triethylamine / methanol

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; sodium methylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol;
DOI:10.1039/c1ob06148h