7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one

Base Information

Chemical Name:7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one
CAS No.:1314304-15-8
Molecular Formula:C₁₉H₂₅NO₃S
Molecular Weight:347.478
Hs Code.:

Synonyms:7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one

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Chemical Property of 7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one

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Technology Process of 7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one

There total 7 articles about 7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1314304-10-3
7-allyl-6-tosyl-6-azaspiro[4.5]dec-8-en-10-one

: 1314304-15-8
7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one

Guidance literature:: With (triphenylphosphine)copper(I) hydride hexamer; In water; benzene; at 20 ℃; chemoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.047

Reference yield:

: 1314303-92-8
2-(1-azidocyclopentyl)furan

: 1314304-15-8
7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 10 - 20 °C / Inert atmosphere

4: boron trifluoride diethyl etherate / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

5: (triphenylphosphine)copper(I) hydride hexamer / water; benzene / 20 °C / Inert atmosphere

With (triphenylphosphine)copper(I) hydride hexamer; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; water; ethyl acetate; benzene; 3: aza-Achmatowicz rearrangement;
DOI:10.1016/j.tet.2011.04.047

Reference yield:

: 79575-90-9
(+/-)-2-(1'-hydroxy-cyclopentyl)-furane

: 1314304-15-8
7-allyl-6-tosyl-6-azaspiro[4.5]decan-10-one

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen azide; sulfuric acid / benzene / 0.08 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / chloroform / 10 - 20 °C / Inert atmosphere

5: boron trifluoride diethyl etherate / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

6: (triphenylphosphine)copper(I) hydride hexamer / water; benzene / 20 °C / Inert atmosphere

With hydrogen azide; (triphenylphosphine)copper(I) hydride hexamer; sulfuric acid; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; water; ethyl acetate; benzene; 4: aza-Achmatowicz rearrangement;
DOI:10.1016/j.tet.2011.04.047