N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester
CAS No.:202811-39-0
Molecular Formula:C₃₇H₄₉N₅O₅
Molecular Weight:643.827
Hs Code.:

N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

Synonyms:N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

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Chemical Property of N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

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Technology Process of N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

There total 8 articles about N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 202811-38-9
N-[(3E)-4-(N-((1R)-1-(N-(2-(2-((((9H-9-fluorenyl)methoxycarbonyl)amino)acetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

: 202811-39-0
N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

Guidance literature:: With 2,2',2''-triaminotriethylamine; In dichloromethane; at 20 ℃; for 1.2h;
DOI:10.1016/S0223-5234(00)00160-4

Reference yield:

: 22908-49-2
2-(2-methylamino-ethyl)-phenylamine

: 202811-39-0
N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 38 percent / aq. NaOH / tetrahydrofuran / 16 h / 20 °C

2.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0.5 h / 0 °C

2.2: 96 percent / CH₂Cl₂ / 16 h / 0 - 20 °C

3.1: HCl / ethyl acetate / 2 h / 20 °C

4.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 0.42 h / 0 °C

4.2: 98 percent / iPr₂NEt / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

5.1: HCl / ethyl acetate / 2.25 h / 20 °C

6.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

6.2: 365 mg / iPr₂NEt / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

7.1: 72 percent / tris(2-aminoethyl)amine / CH₂Cl₂ / 1.2 h / 20 °C

With hydrogenchloride; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 2,2',2''-triaminotriethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Addition / 2.2: Condensation / 3.1: solvolysis / 4.1: Addition / 4.2: Condensation / 5.1: solvolysis / 6.1: Addition / 6.2: Condensation / 7.1: saponification;
DOI:10.1016/S0223-5234(00)00160-4

Reference yield:

: 147577-61-5
(2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid

: 202811-39-0
N-[(3E)-4-(N-((1R)-1-(N-(2-(2-(2-aminoacetylamino)phenyl)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 0.42 h / 0 °C

1.2: 98 percent / iPr₂NEt / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

2.1: HCl / ethyl acetate / 2.25 h / 20 °C

3.1: 1-hydroxy-7-azabenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

3.2: 365 mg / iPr₂NEt / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

4.1: 72 percent / tris(2-aminoethyl)amine / CH₂Cl₂ / 1.2 h / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 2,2',2''-triaminotriethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.1: Addition / 1.2: Condensation / 2.1: solvolysis / 3.1: Addition / 3.2: Condensation / 4.1: saponification;
DOI:10.1016/S0223-5234(00)00160-4