Technology Process of (2R)-N-[6-Methoxy-5-(1H-pyrazol-4-yl)-2-pyridyl]-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepin-8-amine
There total 10 articles about (2R)-N-[6-Methoxy-5-(1H-pyrazol-4-yl)-2-pyridyl]-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepin-8-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 4-[2-methoxy-6-[[(2R)-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepin-8-yl]amino]-3-pyridyl]pyrazole-1-carboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
Cooling with ice;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium / 4 h / -20 - 0 °C
1.2: 24 h / 120 °C / Sealed tube
2.1: potassium carbonate / 1,2-dimethoxyethane; water / 90 °C / Sealed tube
3.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 145 °C / Inert atmosphere; Microwave
4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
With
sodium; potassium carbonate; caesium carbonate; trifluoroacetic acid;
palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C
2.1: acetic acid / tetrahydrofuran / 0.67 h
2.2: 0.67 h
3.1: sodium hydride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Cooling with ice
4.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 145 °C / Inert atmosphere; Microwave
5.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
With
sodium hydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
![tert-butyl 4-[2-methoxy-6-[[(2R)-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepin-8-yl]amino]-3-pyridyl]pyrazole-1-carboxylate](/Databaselist/images/loading.webp)
