(R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

Base Information

Chemical Name:(R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide
CAS No.:1421840-37-0
Molecular Formula:C₂₇H₂₅O₄P
Molecular Weight:444.467
Hs Code.:

Synonyms:(R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

Suppliers and Price of (R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

There total 10 articles about (R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1421840-46-1
((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate

: 755017-61-9
2'-bromo-2,6-dimethoxybiphenyl

: 1421840-37-0
(R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

Guidance literature:: 2'-bromo-2,6-dimethoxybiphenyl; With n-butyllithium; In tetrahydrofuran; hexane; at -70 - -25 ℃; Inert atmosphere;

((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate; In tetrahydrofuran; hexane; at -70 ℃; Inert atmosphere;
DOI:10.1021/ja312352p

Reference yield:

: C₁₄H₁₅O₂PS

: 1421840-37-0
(R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

: C₂₇H₂₅O₄P

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 12 h / 20 °C

2: tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;
DOI:10.1021/jacs.9b13898

Reference yield:

: C₁₆H₂₁OPS₂

: 1421840-37-0
(R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

: C₂₇H₂₅O₄P

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / 12 h / 20 °C

3.1: tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

With potassium tert-butylate; In tetrahydrofuran;
DOI:10.1021/jacs.9b13898