((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate

Base Information

• Chemical Name: ((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate
• CAS No.: 1421840-46-1
• Molecular Formula: C₂₈H₂₇ClNO₅PS
• Molecular Weight: 556.019

Synonyms:((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate

Chemical Property of ((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate

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Technology Process of ((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate

There total 6 articles about ((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C21H19ClNO4PS (1421840-45-0) + 2-methoxyphenylmagnesium bromide (16750-63-3) → ((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate (1421840-46-1)

Guidance literature:

C₂₁H₁₉ClNO₄PS; 2-methoxyphenylmagnesium bromide; In tetrahydrofuran; at -20 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/ja312352p

Reference yield:

(R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide (1421840-44-9) → ((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate (1421840-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3,5-Lutidine / dichloromethane / -10 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / -20 °C / Inert atmosphere

2.2: Inert atmosphere

With 3,5-Lutidine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja312352p

Reference yield:

P,P-dichlorophenylphosphine oxide (824-72-6) → ((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate (1421840-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3,5-Lutidine / dichloromethane / -10 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / -20 °C / Inert atmosphere

2.2: Inert atmosphere

With 3,5-Lutidine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja312352p

upstream raw materials:

C₂₁H₁₉ClNO₄PS

2-methoxyphenylmagnesium bromide

(R)-2-(1-aminoethyl)-4-chlorophenol

(R)-6-chloro-4-methyl-3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one

Downstream raw materials:

(S_p)-(2-methoxyphenyl)methylphenylphosphine oxide

(R)-(2',6'-dimethoxybiphenyl-2-yl)(2-methoxyphenyl)-(phenyl)phosphine oxide

(S)-(2-methoxyphenyl)(isopropyl)(phenyl)phosphine oxide

(-)-(S_P)-(2-methoxyphenyl)phenylvinylphosphine oxide

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