6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester

Base Information

Chemical Name:6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester
CAS No.:300765-98-4
Molecular Formula:C₃₂H₅₂N₂O₆S₂
Molecular Weight:624.907
Hs Code.:

Synonyms:6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester

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Chemical Property of 6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester

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Technology Process of 6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester

There total 7 articles about 6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 300765-97-3
6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane

: 300765-98-4
6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester

Guidance literature:: With potassium carbonate; potassium iodide; at 20 ℃; for 19h;
DOI:10.1016/S0040-4020(00)00424-5

Reference yield:

: 2-(p-carbomethoxybenzylidine)-2-benzamidoacetonitrile

: 300765-98-4
6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂; NH₃ / Raney Nickel / ethanol / 20 h / 20 °C / 2585.74 - 2844.31 Torr

2: conc. HCl / 48 h / Heating

3: 1.98 g / HCl(gas) / 16 h

4: 68 percent / bis-trimethylsilyl acetamide / benzene / 3 h / 70 - 80 °C

5: 62 percent / NaBH₃CN; HCl / methanol / 2 h / pH 5.0 - 5.3

6: 79 percent / K₂CO₃; KI / 19 h / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium cyanoborohydride; potassium carbonate; bis-(trimethylsilyl)acetamide; potassium iodide; nickel; In methanol; ethanol; benzene; 1: Catalytic hydrogenation / 2: Hydrolysis / 3: Esterification / 4: cyclocondensation / 5: Hydrogenation / 6: Alkylation;
DOI:10.1016/S0040-4020(00)00424-5

Reference yield:

: 4-[5-Imino-2-phenyl-oxazol-(4E)-ylidenemethyl]-benzoic acid methyl ester; hydrochloride

: 300765-98-4
6-(p-carbethoxybenzyl)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazacyclodecane-N,N'-diacetic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 2.9 g / Na₂CO₃; H₂O / 2 h / 0 °C

2: H₂; NH₃ / Raney Nickel / ethanol / 20 h / 20 °C / 2585.74 - 2844.31 Torr

3: conc. HCl / 48 h / Heating

4: 1.98 g / HCl(gas) / 16 h

5: 68 percent / bis-trimethylsilyl acetamide / benzene / 3 h / 70 - 80 °C

6: 62 percent / NaBH₃CN; HCl / methanol / 2 h / pH 5.0 - 5.3

7: 79 percent / K₂CO₃; KI / 19 h / 20 °C

With hydrogenchloride; ammonia; water; hydrogen; sodium cyanoborohydride; sodium carbonate; potassium carbonate; bis-(trimethylsilyl)acetamide; potassium iodide; nickel; In methanol; ethanol; benzene; 1: Hydrolysis / 2: Catalytic hydrogenation / 3: Hydrolysis / 4: Esterification / 5: cyclocondensation / 6: Hydrogenation / 7: Alkylation;
DOI:10.1016/S0040-4020(00)00424-5