3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid

Base Information

• Chemical Name: 3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid
• CAS No.: 1283521-78-7
• Molecular Formula: C₁₆H₁₂N₂O₃
• Molecular Weight: 280.283
• Mol file: 1283521-78-7.mol

Synonyms:3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid

Chemical Property of 3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid

There total 2 articles about 3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalonic acid (528-46-1) + N-4-methylphenylhydrazine (539-44-6) → 3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid (1283521-78-7)

Guidance literature:

In ethanol; water; at 20 ℃; for 15h;

DOI:10.1016/j.bioorg.2019.01.039

Reference yield:

naphthalene (91-20-3,71998-51-1,72931-45-4) → 3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid (1283521-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate; sodium hydroxide; water / 2 h / Reflux

2: ethanol; water / 15 h / 20 °C

With potassium permanganate; water; sodium hydroxide; In ethanol; water;

DOI:10.1016/j.bioorg.2019.01.039

Reference yield:

3-(4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid (1283521-78-7) → C16H11ClN2O2 (1216018-82-4)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1.66667h;

DOI:10.1016/j.tet.2012.10.010

upstream raw materials:

phthalonic acid

N-4-methylphenylhydrazine

naphthalene

Downstream raw materials:

4-amino-2-(4-methylphenyl)phthalazin-1(2H)-one

C₁₆H₁₁ClN₂O₂