azasetron

Base Information

Chemical Name:azasetron
CAS No.:123040-93-7
Molecular Formula:C₁₇H₂₀ClN₃O₃
Molecular Weight:349.817
Hs Code.:
Mol file:123040-93-7.mol

Synonyms:2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, (+)-;

Suppliers and Price of azasetron

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of azasetron

Chemical Property:

Vapor Pressure:3.68E-12mmHg at 25°C
Refractive Index:1.653
Boiling Point:550.4°C at 760 mmHg
Flash Point:286.6°C
PSA：61.88000
Density:1.42g/cm³
LogP:1.91300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of azasetron

There total 10 articles about azasetron which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 6530-09-2
3-aminoquinuclidine dihydrochloride

: 123040-79-9
6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid

: 123040-69-7,123040-93-7,123040-95-9,123039-99-6
azasetron

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 0 - 10 ℃;

Reference yield:

: 141761-83-3
6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid methyl ester

: 123040-69-7,123040-93-7,123040-95-9,123039-99-6
azasetron

Guidance literature:: Multi-step reaction with 3 steps

1: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating

2: SOCl₂, DMF / 1,2-dichloro-ethane / 2 h / 60 °C

3: CHCl₃ / 1 h / Ambient temperature

With sodium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In ethanol; chloroform; 1,2-dichloro-ethane;
DOI:10.1248/cpb.40.624

Reference yield:

: 4068-78-4
methyl 5-chloro-2-hydroxybenzoate

: 123040-69-7,123040-93-7,123040-95-9,123039-99-6
azasetron

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / HNO₃, conc. H₂SO₄ / 1 h / 0 - 5 °C

2: 79 percent / 0.78N aq. NH₄Cl, Fe / toluene / 1 h / 85 - 90 °C

3: aq. NaHCO₃ / CHCl₃ / 2 h / 0 - 10 °C

4: K₂CO₃ / dimethylformamide / 2 h / 70 °C

5: 82.2 percent / K₂CO₃ / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h

6: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating

7: SOCl₂, DMF / 1,2-dichloro-ethane / 2 h / 60 °C

8: CHCl₃ / 1 h / Ambient temperature

With sodium hydroxide; thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; N,N-dimethyl-formamide; In ethanol; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.624