1,2-dibromo-4,4-diethoxy-2-methylbutane

Base Information

• Chemical Name: 1,2-dibromo-4,4-diethoxy-2-methylbutane
• CAS No.: 145572-38-9
• Molecular Formula: C₉H₁₈Br₂O₂
• Molecular Weight: 318.049
• Mol file: 145572-38-9.mol

Synonyms:1,2-dibromo-4,4-diethoxy-2-methylbutane

Chemical Property of 1,2-dibromo-4,4-diethoxy-2-methylbutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-dibromo-4,4-diethoxy-2-methylbutane

There total 2 articles about 1,2-dibromo-4,4-diethoxy-2-methylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,1-diethoxy-3-methyl-3-butene (54340-95-3) → 1,2-dibromo-4,4-diethoxy-2-methylbutane (145572-38-9)

Guidance literature:

With bromine; sodium carbonate; In tetrachloromethane; at 0 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)85614-3

Reference yield:

diethyl phenyl orthoformate (14444-77-0) → 1,2-dibromo-4,4-diethoxy-2-methylbutane (145572-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg / 1) THF, 2 h, RT, 2) THF, RT, 20 h

2: 85 percent / Br₂, Na₂CO₃ / CCl₄ / 0.25 h / 0 °C

With bromine; sodium carbonate; magnesium; In tetrachloromethane;

DOI:10.1016/S0040-4020(01)85614-3

Reference yield:

1,2-dibromo-4,4-diethoxy-2-methylbutane (145572-38-9) → 9-cis vitamin A aldehyde (514-85-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 64 percent / 50percent NaOH, 40percent Bu₄NOH / 4 h / 100 °C

2: 62 percent / hexamethyldisilazane, ISiMe₃ / CCl₄ / 1) 0 deg C, 2 h, 2) RT, 15 h

3: 1) t-BuLi / 1) ether, -70 deg C, 90 min, 2a) ether, -70 deg C, 1 h, 2b) -30 deg C, 1.5 h

4: 1) t-BuLi / 1) ether, -70 deg C, 90 min, 2a) ether, -70 deg C, 1 h, 2b) -30 deg C, 1.5 h

With sodium hydroxide; trimethylsilyl iodide; tetra(n-butyl)ammonium hydroxide; tert.-butyl lithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrachloromethane;

DOI:10.1016/S0040-4020(01)85614-3

upstream raw materials:

1,1-diethoxy-3-methyl-3-butene

diethyl phenyl orthoformate

Downstream raw materials:

9-cis vitamin A aldehyde

13-cis-vitamin A aldehyde

all-trans-Retinal

3-methyl-5-phenyl-penta-2,4-dienal

Refernces