(E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime

Base Information

• Chemical Name: (E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime
• CAS No.: 133902-54-2
• Molecular Formula: C₉H₈N₄O
• Molecular Weight: 188.189
• Mol file: 133902-54-2.mol

Synonyms:(E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime

Chemical Property of (E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime

There total 10 articles about (E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-phenyl-1,2,3-triazole-4-carbaldehyde (34296-51-0) → (E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime (133902-54-2,338757-51-0)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; for 24h; Ambient temperature;

Reference yield:

4-nitrophenyl azide (1516-60-5) → (E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime (133902-54-2,338757-51-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 71 percent / toluene / Heating

2: 36 percent / NaBH₄ / methanol / 1 h / Heating

3: 47 percent / MnO₂ / CH₂Cl₂ / Ambient temperature

4: 51 percent / ethanol / Ambient temperature

5: 2) HCOOH / 1) 80 deg C, DMSO, overnight, 2) H₂O, MeOH, reflux, 12 h

6: 71 percent / hydroxylamine hydrochloride / methanol / 24 h / Ambient temperature

With manganese(IV) oxide; sodium tetrahydroborate; formic acid; hydroxylamine hydrochloride; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

(1-phenyl-1H-1,2,3-triazole-4-yl)methanol (103755-58-4) → (E)-1-phenyl-1H-1,2,3-triazole-4-carbaldehydeoxime (133902-54-2,338757-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / MnO₂ / CH₂Cl₂ / Ambient temperature

2: 71 percent / hydroxylamine hydrochloride / methanol / 24 h / Ambient temperature

With manganese(IV) oxide; hydroxylamine hydrochloride; In methanol; dichloromethane;

upstream raw materials:

1-phenyl-1,2,3-triazole-4-carbaldehyde

4-nitrophenyl azide

(1-phenyl-1H-1,2,3-triazole-4-yl)methanol

1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carboxaldehyde

Downstream raw materials:

1-phenyl-1H-1,2,3-triazole-4-carbonitrile