103755-58-4Relevant academic research and scientific papers
Synthesis of novel 1-benzyl/aryl-4-{[(1-aryl-1H-1,2,3-triazol-4-yl)methoxy]methyl}-1H-1,2,3-triazole derivatives and evaluation of their antimicrobial activity
Reddy,Reddy,Goud,Rao,Premkumar,Supriya
, p. 1424 - 1429 (2016)
A series of 1-benzyl/aryl-4-{[(1-aryl-1H-1,2,3-triazol-4-yl)methoxy]methyl}-1H-1,2,3-triazole derivatives were synthesized via Cu(I) catalyzed reaction between terminal alkyne and substituted aryl or benzyl azides. The synthesized triazoles were character
Triazole-diindolylmethane conjugates as new antitubercular agents: synthesis, bioevaluation, and molecular docking
Danne, Ashruba B.,Choudhari, Amit S.,Chakraborty, Shakti,Sarkar, Dhiman,Khedkar, Vijay M.,Shingate, Bapurao B.
, p. 1114 - 1130 (2018)
We describe the synthesis of novel triazole-incorporated diindolylmethanes (DIMs) using a molecular hybridization approach. The in vitro antitubercular activity of the DIMs against Mycobacterium tuberculosis H37Ra (ATCC 25177) was tested in the active and
Click chemistry: Copper clusters catalyse the cycloaddition of azides with terminal alkynes
Pachon, Laura Duran,Van Maarseveen, Jan H.,Rothenberg, Gadi
, p. 811 - 815 (2005)
Air-stable copper nanoclusters are good catalysts in the Cu(I)-catalysed "click" cycloaddition of azides with terminal alkynes to give 1,4-disubstituted 1,2,3-triazoles. No additional base or reducing agent is required. The reaction kinetics using various
Synthesis, Characterization, and Evaluation of Antibacterial Activity of Ferrocenyl-1,2,3-Triazoles, Triazolium Salts, and Triazolylidene Complexes of Gold(i) and Silver(i)
Hoyer, Carolin,Schwerk, Peter,Suntrup, Lisa,Beerhues, Julia,N?ssler, Maite,Albold, Uta,Dernedde, Jens,Tedin, Karsten,Sarkar, Biprajit
, p. 1373 - 1382 (2021)
1,2,3-triazoles, the corresponding triazolium salts, and the resulting mesoionic carbenes (MICs) of the 1,2,3-triazol-5-ylidene type are at the forefront of contemporary research. In this contribution, we present a comprehensive study involving eight tria
Design and Synthesis of Novel 1,2,3-Triazole- and 2-Isoxazoline-Based Bis-Heterocycles as Immune Potentiators
Ismail, Tabasum,Shafi, Syed,Hyder, Irfan,Sidiq, Tabasum,Khajuria, Anamika,Alam, Sarvar M.,Halmuthur, M. Sampath Kumar
, p. 796 - 807 (2015)
A series of novel bis-heterocycles encompassing isoxazolines and triazoles were synthesized through a novel one-pot procedure that involves in situ generation of nitrile oxide and its 1,3-dipolar cycloaddition to variedly substituted acrylates. The synthe
Copper(II)-benzotriazole coordination compounds in click chemistry: a diagnostic reactivity study
Loukopoulos, Edward,Abdul-Sada, Alaa,Csire, Gizella,Kállay, Csilla,Brookfield, Adam,Tizzard, Graham J.,Coles, Simon J.,Lykakis, Ioannis N.,Kostakis, George E.
, p. 10491 - 10508 (2018)
This diagnostic study aims to shed light on the catalytic activity of a library of Cu(ii) based coordination compounds with benzotriazole-based ligands. We report herein the synthesis and characterization of five new coordination compounds formulated as [CuII(L4)(MeCN)2(CF3SO3)2] (1), [CuII(L5)2(CF3SO3)2] (2), [CuII(L6)2(MeCN)(CF3SO3)]·(CF3SO3) (3), [CuII(L6)2(H2O)(CF3SO3)]·(CF3SO3)·2(Me2CO) (4), and [CuI4(L1)2(L1′)2(CF3SO3)2]2·4(CF3SO3)·8(Me2CO) (5), derived from similar nitrogen-based ligands. The homogeneous catalytic activity of these compounds along with our previously reported coordination compounds (6-13), derived from similar ligands, is tested against the well-known Cu(i)-catalysed azide-alkyne cycloaddition reaction. The optimal catalyst [CuII(L1)2(CF3SO3)2] (10) activates the reaction to afford 1,4-disubstituted 1,2,3-triazoles with yields up to 98% and without requiring a reducing agent. Various control experiments are performed to optimize the method and examine parameters such as ligand variation, metal coordination geometry and environment, in order to elucidate the behaviour of the catalytic system.
An efficient NaHSO3-promoted protocol for chemoselective synthesis of 2-substituted benzimidazoles in water
Jiang, Yu-Qin,Jia, Shu-Hong,Li, Xi-Yong,Sun, Ya-Min,Li, Wei,Zhang, Wei-Wei,Xu, Gui-Qing
, p. 1265 - 1276 (2018)
An efficient protocol for chemoselective synthesis of 2-substituted benzimidazoles from a variety of aliphatic/aromatic/ heteroaryl aldehydes and o-phenylenediamine derivatives promoted by NaHSO3 in water had been developed. The amount of NaHSO3 had a great effect on the reaction selectivity of 2-substituted benzimidazole and 1,2-disubstituted benzimidazole when the reaction was carried out in water. When the amount of the NaHSO3 was more than 11 equivalents, the 2-substituted benzimidazole could be highly selectively formed as the sole product. NaHSO3 was firstly reacted with aldehyde to form the aldehyde sodium bisulfite, which reacted with o-phenylenediamine to form the 2-substituted benzimidazole and inhibited the formation of 1,2-disubstituted benzimidazole. This protocol solved the poor selectivity problem appearing in traditional method when cyclocondensation between o-phenylenediamine and aldehydes. The method also had advantage of simple work up by filtrating the single 2-substituted benzimidazole precipitates from reaction mixture at the end of the reaction without further purification. In addition, the method was applicable to both electron-rich and electron-poor starting materials, which was successfully used for synthesizing nine novel 2-substituted benzimidazole derivatives containing a 1,2,3-triazole moiety. They were characterized by NMR, IR and HRMS spectrum. Moreover, this method had been applied to a large scale synthesis of 2-substituted benzimidazole derivatives.
Ultrasound assisted rapid synthesis, biological evaluation, and molecular docking study of new 1,2,3-triazolyl pyrano[2,3-c]pyrazoles as antifungal and antioxidant agent
Khare, Smita P.,Deshmukh, Tejshri R.,Sangshetti, Jaiprakash N.,Khedkar, Vijay M.,Shingate, Bapurao B.
, p. 2521 - 2537 (2019)
In search of new generation of triazole based antifungal agents, synthesis of series of new 1,2,3-triazolyl pyrano[2,3-c]pyrazoles under ultrasonic irradiation using NaHCO3 has been reported. The bioevaluation results indicate that, the compoun
Magnetically recoverable chitosan-stabilised copper-iron oxide nanocomposite material as an efficient heterogeneous catalyst for azide-alkyne cycloaddition reactions
Chetia, Mitali,Ali, Abdul Aziz,Bhuyan, Diganta,Saikia, Lakshi,Sarma, Diganta
, p. 5902 - 5907 (2015)
Chitosan-stabilised copper-iron oxide nanocomposite material is found to be a very efficient recyclable/reusable heterogeneous catalyst for azide-alkyne cycloaddition reaction under mild conditions. The as-synthesized nanocomposite material is magneticall
New 1,2,3-triazole-linked tetrahydrobenzo[b]pyran derivatives: Facile synthesis, biological evaluation and molecular docking study
Khare, Smita P.,Deshmukh, Tejshri R.,Akolkar, Satish V.,Sangshetti, Jaiprakash N.,Khedkar, Vijay M.,Shingate, Bapurao B.
, p. 5159 - 5182 (2019)
Abstract: An efficient ultrasound-promoted one-pot three-component synthesis of a series of new 1,2,3-triazole-linked tetrahydrobenzo[b]pyran derivatives as antifungal and antioxidant agents using NaHCO3 has been described for the first time. T
