103755-58-4

Basic information

• Product Name: (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol
• Synonyms: (1-PHENYL-1H-1,2,3-TRIAZOL-4-YL)METHANOL;1-Phenyl-1H-1,2,3-Triazol-4-yl
• CAS NO: 103755-58-4
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Product Categories: Heterocyclic Series;API intermediates;Pyrrodiazole
• Mol File: 103755-58-4.mol
• Article Data: 70

Chemical Properties

• Melting Point: 114-116°C
• Boiling Point: 379.9 °C at 760 mmHg
• Flash Point: 183.6 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 1.9E-06mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.96±0.10(Predicted)
• CAS DataBase Reference: (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol(103755-58-4)
• EPA Substance Registry System: (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol(103755-58-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 103755-58-4(Hazardous Substances Data)

Usage

General Description

(1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, also known as PTM, is a chemical compound with the molecular formula C9H9N3O. It is used in the synthesis of various pharmaceuticals, agrochemicals, and materials due to its unique properties and reactivity. PTM can also be used as a building block in the preparation of triazolyl compounds and can serve as a ligand in coordination chemistry. Its versatile nature makes it a valuable component in the development of new drugs and materials. Additionally, PTM has been studied for its potential antibacterial and antifungal properties, making it a promising candidate for further research in the field of medicinal chemistry.

InChI:InChI=1/C9H9N3O/c13-7-8-6-12(11-10-8)9-4-2-1-3-5-9/h1-6,13H,7H2

Upstream product

• 107-19-7 propargyl alcohol 
• 622-37-7 Phenyl azide 
• 71-43-2 benzene 
• 591-50-4 iodobenzene 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 2055-52-9 methyl 1-phenyl-1H-1,2,3-triazole-4-carboxylate 
• 62-53-3 aniline 
• 4915-97-3 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 622-79-7 benzyl azide 
• 34296-51-0 1-phenyl-1,2,3-triazole-4-carbaldehyde 

Downstream Products

• 1325724-94-4 (E)-N'-[(1-phenyl-1H-1,2,3-triazole-4-yl)methylene]isonicotinoylhydrazide 
• 1448245-62-2 2-hydroxymethyl-1-[2-hydroxy-3-((1-phenyl-1H-[1,2,3]triazol-4-yl)methoxy)propyl]piperidine-3,4,5-triol 
• 1443104-10-6 2-(((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)methyl)-amino-1,4-naphthoquinone 
• 1433882-47-3 C₁₀H₁₂N₃O⁽¹⁺⁾*I^(1-) 
• 1338831-24-5 (1-phenyl-1H-1,2,3-triazol-4-yl)methyl 4-methylbenzenesulfonate 
• 1338831-32-5 1-phenyl-4-[(4-phenyl-1H-1,2,3-triazol-1-yl)methyl]-1H-1,2,3-triazole 
• 1338831-29-0 C₁₂H₁₂N₆O 
• 924868-97-3 4-chloromethyl-1-phenyl-1H-1,2,3-triazole 
• 133902-49-5 (4-Methoxy-phenyl)-[1-(1-phenyl-1H-[1,2,3]triazol-4-yl)-meth-(E)-ylidene]-amine 
• 133902-53-1 1-phenyl-1,2,3-triazole-4-carbaldehyde (N-phenyl)hydrazone 
• 133902-48-4 Benzyl-[1-(1-phenyl-1H-[1,2,3]triazol-4-yl)-meth-(E)-ylidene]-amine 
• 133902-55-3 C₁₁H₁₀N₄O₂ 
• 133902-47-3 tert-Butyl-[1-(1-phenyl-1H-[1,2,3]triazol-4-yl)-meth-(E)-ylidene]-amine 
• 133902-57-5 [1-(1-Ethyl-1H-[1,2,3]triazol-4-yl)-meth-(E)-ylidene]-phenyl-amine 

Relevant articles and documents

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This diagnostic study aims to shed light on the catalytic activity of a library of Cu(ii) based coordination compounds with benzotriazole-based ligands. We report herein the synthesis and characterization of five new coordination compounds formulated as [CuII(L4)(MeCN)2(CF3SO3)2] (1), [CuII(L5)2(CF3SO3)2] (2), [CuII(L6)2(MeCN)(CF3SO3)]·(CF3SO3) (3), [CuII(L6)2(H2O)(CF3SO3)]·(CF3SO3)·2(Me2CO) (4), and [CuI4(L1)2(L1′)2(CF3SO3)2]2·4(CF3SO3)·8(Me2CO) (5), derived from similar nitrogen-based ligands. The homogeneous catalytic activity of these compounds along with our previously reported coordination compounds (6-13), derived from similar ligands, is tested against the well-known Cu(i)-catalysed azide-alkyne cycloaddition reaction. The optimal catalyst [CuII(L1)2(CF3SO3)2] (10) activates the reaction to afford 1,4-disubstituted 1,2,3-triazoles with yields up to 98% and without requiring a reducing agent. Various control experiments are performed to optimize the method and examine parameters such as ligand variation, metal coordination geometry and environment, in order to elucidate the behaviour of the catalytic system.

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